USP15生物学功能的研究进展

Research Progress in Tumor and Immune Mechanism of USP15

去泛素化酶(DUBs)是体内分解蛋白泛素链的一类蛋白酶体系,对蛋白泛素化降解过程起校正作用。泛素特异性蛋白酶(USP)家族是DUBs中最大的家族,通过多种途径参与免疫应答,且与一些疾病和肿瘤的发生具有明显相关性。USP15是USP家族的重要组成部分,参与调节转化生长因子β、p53、核因子κB等重要的信号转导通路,与一些肿瘤的发生发展相关。USP15也可通过调节I型干扰素产生和T细胞活化参与免疫反应,并具有多种重要生物学功能,包括维持基因稳定性、调节转录因子及抗病毒等重要的细胞活动。

Deubiquitinases(DUBs) are a class of enzyme protein systems that decompose protein ubiquitin chains in vivo,correcting the process of protein ubiquitination and degradation.The ubiquitin-specific protease(USP) family is the largest family in DUBs,which is involved in the immune response through a variety of pathways and has a significant correlation with the occurrence of some diseases and tumors.USP15 is an important component of the USP family,participating in regulating important signal transduction pathways of transforming growth factor-β,p53 and nuclear factor-κ B,associated with the development of some tumors.USP15 also participates in immune responses by regulating type I interferon production and T cell activation,and has a variety of important biological functions,including maintaining gene stability,regulating transcription factors,and antiviral activity,and other important cellular activities.