不同抗VEGF药物(康柏西普对比雷珠单抗)对玻璃体视网膜手术辅助作用差异性分析

Differential analysis of the auxiliary effects of different anti-VEGF drugs(Compaqip vs. ranibizumab) on vitreoretinal surgery

目的探讨不同抗VEGF药物(康柏西普对比雷珠单抗)对玻璃体视网膜手术辅助作用研究。方法选取我院增殖性糖尿病视网膜病变患者71例(71眼),均行玻璃体视网膜手术治疗,按照随机数字表法分为康柏西普组36例及雷珠单抗组35例,观察比较两组手术前后视力及黄斑中心凹厚度(CMT)变化情况,并统计两组药物注射次数及并发症发生情况。结果术后1个月康柏西普组与雷珠单抗组视力及CMT优于术前(P<0.05),术前及术后1个月两组视力及CMT组间比较,差异无统计学意义(P>0.05);康柏西普组注射次数小于雷珠单抗组(P<0.05);康柏西普组并发症发生率为8.33%(3/36),雷珠单抗组并发症发生率为8.57%(3/35),组间比较差异无统计学意义(P>0.05)。结论康柏西普相比雷珠单抗辅助玻璃体视网膜手术,可减少药物注射次数,但二者在视力及CMT改善方面效果相当,可依据患者具体情况灵活选择抗VEGF药物。

Objective To investigate the clinical efficacy and safety of laser vitreolysis combined with iodized lecithin tablets for the treatment of vitreous opacity. Method We retrospectively analyzed clinical data from August 2016 to May 2017 for laser vitreolysis with iodized lecithin tablets in non-allergic patients from our hospital. All patients underwent intraocular pressure, fundus examination, and B-scan before and after surgery. For treatment, we used an Ultra-Q YAG laser at 2.5-5.0 mJ directed at the vitreous floaters, with the appropriate energy level determined at the point when bubbles form in the vitreous cavity. The patients were treated up to two times with a second treatment prescribed one month after the first for patients who were not completely cured. After each treatment 1 month of iodized lecithin tablets 3.0mg, tid were prescribed. Results Among 48 cases of treatment, 1 month after the start of treatment 24 cases (24%) were cured, 16 cases (33.3%) saw improvement, and 8 cases (16.7%) saw no improvement, with a total effective rate of 83.3%. After 2 months from the start of treatment, 33 cases (68.75%) were cured, 13 cases (27.8%) saw some improvement, and 2 cases (4.17%) saw no improvement, with a total effective rate of 95.83%. No complications occurred in any of the cases. Conclusion The method of laser vitreolysis combined with iodized lecithin tablets for the treatment of vitreous opacity is simple and effective, safe and economical, and also free of complications. It is worthy of clinical promotion.