重组基因活菌冻干因子联合深度水解奶粉治疗牛奶蛋白过敏所致迁延性腹泻的临床效果

Clinical effect of recombinant genes live bacteria lyophilization factor combined with deep hydrolyzed milk powder in the treatment of persistent diarrhea caused by milk protein allergy

目的观察重组基因活菌冻干因子联合深度水解奶粉治疗牛奶蛋白过敏所致迁延性腹泻的效果。方法选取2017年6月至2018年9月我院收治的120例牛奶蛋白过敏所致迁延性腹泻患儿为研究对象,随机将其分为A、B组,每组60例。A组给予深度水解奶粉喂养治疗,B组联合使用重组基因活菌冻干因子治疗。比较两组的治疗效果。结果治疗3月后,两组患儿Ig E水平及牛奶过敏指数均降低,且B组低于A组(P<0.05);两组患儿腹泻、胀气、肠绞痛消失时间无显著差异(P>0.05);A组患儿的复发率显著高于B组(P<0.05)。结论重组基因活菌冻干因子联合深度水解奶粉治疗小儿因牛奶蛋白过敏所致的迁延性腹泻效果显著,值得临床推广。

Objective To observe the clinical effect of recombinant genes live bacteria lyophilization factor combined with deep hydrolyzed milk powder in the treatment of persistent diarrhea caused by milk protein allergy.Methods A total of 120 children with persistent diarrhea caused by milk protein allergy admitted in our hospital from June 2017 to September 2018 were selected as the study objects and randomly divided into group A and group B,with 60 cases in each group.The group A was treated with deep hydrolyzed milk powder,and the group B was treated with recombinant genes live bacteria lyophilization factor.The therapeutic effects of the two groups were compared.Results After 3 months of treatment,the levels of IgE and milk allergy index in the two groups decreased,and those in the group B were lower than the group A(P<0.05).There were no significant differences in the disappearing time of diarrhea,flatulence and colic between the two groups (P>0.05).The recurrence rate in the group A was significantly higher than that in the group B (P<0.05).Conclusion Recombinant genes live bacteria lyophilization factor combined with deep hydrolyzed milk powder in the treatment of children with persistent diarrhea caused by milk protein allergy has a significant effect,which is worthy of clinical promotion.