消石利胆胶囊联合熊去氧胆酸胶囊治疗慢性结石性胆囊炎的临床效果

Clinical effect of Xiaoshi Lidan capsules combined with ursodeoxycholic acid capsules on chronic calculous cholecystitis

目的探究消石利胆胶囊联合熊去氧胆酸胶囊治疗慢性结石性胆囊炎的临床效果。方法选取2014年7月至2017年10月我院收治的90例慢性结石性胆囊炎患者作为研究对象,采用随机数字表法将其分为观察组和对照组,各45例。对照组予以熊去氧胆酸胶囊治疗,观察组予以熊去氧胆酸胶囊联合消石利胆胶囊治疗。比较两组溶石效果及临床疗效。比较两组治疗前及治疗6个月后症状积分、PRI、PPI评分以及血清IL-6、hs-CRP、TNF-α的水平。结果治疗6个月后,两组腹胀、恶心呕吐、右上腹隐痛积分均降低,且观察组明显低于对照组(P<0.05)。观察组患者溶石总有效率显著高于对照组,差异具有统计学意义(P<0.05)。观察组的治疗总有效率为84.44%,显著高于对照组的64.44%(P<0.05)。治疗6个月后,两组的PRI、PPI评分、血清IL-6、hs-CRP、TNF-α水平均降低,且观察组明显低于对照组,差异具有统计学意义(P<0.05)。结论消石利胆胶囊联合熊去氧胆酸胶囊治疗慢性结石性胆囊炎的效果显著,可提高溶石总有效率,明显缓解临床症状,减轻炎症反应,值得临床推广应用。

Objective To explore the clinical effect of Xiaoshi Lidan capsules combined with ursodeoxycholic acid capsules on chronic calculous cholecystitis.Methods Ninety patients with chronic calculous cholecystitis admitted in our hospital from July 2014 to October 2017 were selected as the research objects.The patients were divided into observation group and control group by random number table method,with 45 cases in each group.The control group was treated with ursodeoxycholic acid capsules,while the observation group was treated with ursodeoxycholic acid capsules and Xiaoshi Lidan capsules.The litholysis efficiency and clinical efficacy were compared between the two groups.The symptom scores,scores of PRI and PPI,levels of serum IL-6,hs-CRP and TNF-α in both groups were compared before treatment and after 6 months of treatment.Results After 6 months of treatment,the scores of abdominal distension,nausea and vomiting,right upper abdominal pain in both groups decreased,and those of the observation group were significantly lower than the control group (P<0.05).The total effective rate of litholysis in the observation group was significantly higher than that in the control group (P<0.05).The total effective rate of treatment in the observation group was 84.44%,which was significantly higher than 64.44% in the control group,the difference was statistically significant (P<0.05).After 6 months of treatment,the scores of PRI and PPI,the levels of serum IL-6,hs-CRP and TNF-α of the two groups all decreased,and those of the observation group were significantly lower than the control group (P<0.05).Conclusion Xiaoshi Lidan capsules combined with ursodeoxycholic acid capsules is effective in the treatment of chronic calculous cholecystitis.It can improve the total effective rate of litholysis,relieve the clinical symptoms and alleviate the inflammatory reaction,which is worthy of clinical promotion and application.