不对称催化合成2-【【3-{[3-氯-5-(三氟甲基)吡啶-2-基]-氧基}苯氧基】(苯基)甲基】丙烯酸甲酯

Synthesis of Methyl 2-((3-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenoxy(phenyl)methyl) acrylate by Asymmetric Catalysis

以苯甲醛、丙烯酸甲酯、2,3-二氯-5-三氟甲基吡啶和间苯二酚为原料,分别合成了MBH乙酸酯( 6 )和取代苯酚( 9 );在(DHQD) 2 PHAL催化下, 6和9 经不对称反应立体选择性合成了2-【【3-{[3-氯-5-(三氟甲基)吡啶-2-基]-氧基}苯氧基】(苯基)甲基】丙烯酸甲酯,产率50%, ee 94%,其结构经 1 H NMR, 13C NMR和HR-MS确证。

MBH acetate( 6 ) and substituted phenol( 9 ) were synthesized from benzaldehyde, methyl acrylate, 2,3-dichloro-5-trifluoromethyl pyridine and resorcinol, respectively, and then 2-((3-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)-phenoxy (phenyl)methyl)-acrylate, with yield of 50% and ee of 93.5%, was stereoselectively synthesized by reaction of 6 and 9 catalyzed by (DHQD) 2 PHAL. The structure was confirmed by 1 H NMR, 13 C NMR and HR-MS.