低分子肝素钙治疗孕产期深静脉血栓对炎性因子的影响

Effect of Low-molecular-weight Heparin Calcium on Inflammatory Factors in Pregnant and Parturient Patients with Deep Venous Thrombosis

目的探讨在孕产期深静脉血栓的治疗上,低分子肝素钙的临床价值。方法将中国人民解放军第一五九医院诊治的孕产期深静脉血栓患者(共80例)依照随机双盲分组法分成2组(各40例),其中,参照组接受常规抗凝治疗,治疗组与此同时另接受低分子肝素钙治疗,对两组患者治疗成效予以评价。结果两组治疗前的TNF-α、IL-6、IL-1对比,差异无统计学意义(P>0.05);治疗组治疗后的TNF-α、IL-6、IL-1均显著低于参照组,差异具有统计学意义(P<0.05);治疗组总有效率(95.00%)显著高于参照组(77.50%),差异具有统计学意义(P<0.05)。结论在孕产期深静脉血栓的治疗上,低分子肝素钙的应用效果突出,可使患者炎性反应得到显著减轻。

Objective To investigate the clinical value of low molecular weight heparin calcium in the treatment of deep venous thrombosis during pregnancy and delivery.Methods 80 patients with deep venous thrombosis during pregnancy and delivery were divided into two groups(40 cases in each group)according to the randomized double-blind grouping method.The control group received routine anticoagulant therapy,while the treatment group received low molecular weight heparin calcium treatment at the same time.The curative effect of two groups was evaluated.Results There was no significant difference in TNF-α,IL-6 and IL-1 between the two groups before treatment(P>0.05),and the TNF-α,IL-6 and IL-1 in the treatment group were significantly lower than those in the control group.The total effective rate in the treatment group(95.00%)was significantly higher than that in the control group(77.50%),and the difference was statistically significant(P<0.05).Conclusion In the treatment of deep venous thrombosis during pregnancy and parturition,the application of low molecular weight heparin calcium is very effective and can significantly alleviate the inflammatory reaction of the patients.