腹腔镜手术治疗急性结石性胆囊炎对炎性因子水平及胃肠功能的影响

Effect of Laparoscopic Surgery on Inflammatory Factors and Gastrointestinal Function in Patients with Acute Calculous Cholecystitis

目的探讨腹腔镜手术治疗急性结石性胆囊炎对炎性因子水平及胃肠功能的影响。方法将南阳市第一人民医院收治的急性结石性胆囊炎患者90例按随机数字表达法分为两组(每组45例)。对照组行开腹胆囊切除术,观察组行腹腔镜胆囊切除术。对各组患者胃肠功能、炎症因子及并发症情况进行比较。结果两组患者手术后的hs-CRP、TNF-α与同组手术前比较有所升高,对照组升高更为显著,两组患者术后炎症因子表达水平比较差异有统计学意义;手术后观察组的进食时间、排气时间、排便时间、肠鸣音时间与对照组比较有明显缩短;观察组术后并发症总发生率为6.67%,低于对照组22.22%,两组比较差异有统计学意义。结论腹腔镜手术治疗急性结石性胆囊炎,可有效缩短胃肠功能恢复时间,相较开腹手术炎症因子水平更低,术后并发症更少。

Objective To investigate the effect of laparoscopic operation on inflammatory factors and gastrointestinal function in patients with acute calculous cholecystitis.Methods 90 patients with acute calculous cholecystitis were randomly divided into two groups(45 cases in each group).Open cholecystectomy was performed in the control group,and laparoscopic cholecystectomy was performed in the observation group.The gastrointestinal function,inflammatory factors and complications of each group were compared.Results The levels of hs-CRP and TNF-αin the two groups after operation were higher than those in the same group,especially in the control group.The expression of inflammatory factors in the two groups was higher than that in the control group.The feeding time,exhaust time,defecation time and bowel sound time in the observation group were significantly shorter than those in the control group.The total incidence of postoperative complications in the observation group was 6.67%,which was lower than that in the control group(22.22%).The difference between the two groups was statistically significant.Conclusion Laparoscopic surgery for acute calculous cholecystitis can effectively shorten the recovery time of gastrointestinal function,with the lower level of inflammatory factors and less postoperative complications than open surgery.