盐酸替罗非班在ST段抬高型心肌梗死患者行PCI术中的应用效果

Effect of Tirofiban Hydrochloride on PCI in Patients with STEMI

目的探究对ST段抬高型心肌梗死(STEMI)患者行以经皮冠状动脉介入治疗(PCI)术中使用盐酸替罗非班治疗的效果。方法抽取来佛山市高明区人民医院就诊的84例STEMI患者,按随机法分成对照组、研究组,每组患者各42例,两组患者均予以PCI术,术中对照组予以常规药物治疗,而研究组在此基础上予以盐酸替罗非班进行治疗,观察两组患者的治疗效果。结果经治疗后,研究组患者的左室射血分数(LVEF)、左室舒张末内径(LVDd)、活化部分凝血活酶时间(APTT)情况优于对照组,且治疗后心脏不良反应发生率低于对照组,差异有统计学意义(P<0.05);但两组患者的血小板、血红蛋白情况差异无统计学意义(P>0.05)。结论对STEMI患者予以盐酸替罗非班治疗,可有效改善患者的心肌功能,值得推广运用。

Objective To explore the effect of tirofiban hydrochloride during PCI for STEMI patients.Methods 84 patients with STEMI were randomly divided into control group(n=42)and study group(n=42).The patients in both groups were treated with percutaneous coronary intervention(PCI).On this basis,the study group were treated with tirofiban hydrochloride.The therapeutic effect of the two groups was observed.Results After treatment,left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVDd),activated partial thromboplastin time(APTT)were better than that of the control group,and the incidence of adverse cardiac reaction after treatment was lower than that of the control group(P<0.05).But there was no significant difference in platelet and hemoglobin between the two groups(P>0.05).Conclusion The treatment of tirofiban hydrochloride in STEMI patients can effectively improve the myocardial function of patients and is worth popularizing.