下腔静脉滤器置入、导管溶栓术联合利伐沙班片抗凝在急性下肢深静脉血栓(DVT)治疗中的安全性及有效性

Safety and Efficacy of inferior Vena Cava Filter Placement,Catheter Thrombolysis combined with Rivaroxaban Tablets Anticoagulation in the Treatment of acute deep venous Thrombosis of lower Extremities (DVT)

目的:探究下腔静脉滤器置入与导管溶栓术联合利伐沙班片抗凝疗法治疗急性下肢深静脉血栓的效果以及安全性。方法:回顾性收集我院于2016年3月-2018年2月收治的100例急性下肢深静脉血栓患者的临床资料,根据治疗方法分组,对照组患者接受导管溶栓术联合利伐沙班片服用,观察组患者在对照组基础上给予下腔静脉滤器置入,收集整理两组的治疗效果、并发症发生率。结果:治疗前、治疗3天、7天后,两组下肢健侧与患侧肢体周径差比较差异无统计学意义,且两组住院时间差异不明显,P>0.05;但治疗3天、7天后,与治疗前比较两组的肢体周径差均明显缩小,P<0.05;两组治疗期间均未出现严重不良反应,未出现明显不良反应。结论:下腔静脉滤器置入、导管溶栓术和利伐沙班片联合治疗急性下肢深静脉血栓疗效确切,有助于促进血栓溶解,缩短住院时间,且安全性高,值得推广。

Objective: To investigate the efficacy and safety of inferior vena cava filter implantation and catheter thrombolysis combined with rivaroxaban tablets anticoagulation therapy in the treatment of acute deep venous thrombosis of lower limbs. Methods: The clinical data of100 patients with acute deep venous thrombosis of lower limbs admitted to our hospital from March2016 to February 2018 were retrospectively collected,according to the treatment methods,the patients in the control group received catheter thrombolysis combined with rivaroxaban tablets.The patients in the observation group received inferior vena cava filter implantation on the basis of the control group,and the treatment effect and complication rate of the two groups were collected and sorted out. Results: Before treatment,3 days after treatment and 7 days after treatment,there was no statistically significant difference in the peripheral diameter difference between the healthy and affected limbs of the two groups, and the difference in hospitalization time between the two groups was not significant,p> 0.05.However, after3 days and 7 days of treatment,the difference in limb circumference between the two groups was significantly reduced compared with that before treatment,p< 0.05.There were no serious adverse reactions and no obvious adverse reactions in the two groups during the treatment. Conclusion: The combination of inferior vena cava filter implantation,catheter thrombolysis and rivaroxaban tablets has definite curative effect in treating acute deep venous thrombosis of lower limbs,which is helpful to promote thrombolysis,shorten hospitalization time,and has high safety and is worthy of promotion.