阿魏酸哌嗪片联合黄芪注射液治疗急性肾衰竭临床研究

Clinical Study of Piperazine Ferulate Tablets Combined with Astragalus Injection in the Treatment of Acute Renal Failure

目的:探讨阿魏酸哌嗪片联合黄芪注射液对急性肾衰竭患者β2微球蛋白、NGAL及临床疗效的影响。方法:选取我院肾内科以急性肾衰竭为诊断住院治疗的患者,随机分为两组,每组41例,对照组予血液透析等临床常规治疗;观察组联合应用阿魏酸哌嗪片和黄芪注射液治疗,疗程2周。观察两组患者治疗前后实验室指标及临床疗效。结果:与对照组比较,观察组患者治疗后血浆内皮素、24h尿蛋白定量、BUN、Scr、Cys-C、β2微球蛋白、NGAL水平低于对照组,观察组死亡率明显低于对照组(P<0.05);观察组血红蛋白及治愈率明显高于对照组(P<0.05)。结论:阿魏酸哌嗪片联合黄芪注射液能有效降低急性肾衰竭患者β2微球蛋白、NGAL水平,改善肾功能,提高治愈率,降低死亡率。

Objective: To investigate the effects of piperazine ferulate tablets combined with Astragalus injection on β2 microglobulin and NGAL in patients with acute renal failure. Methods: Patients with acute renal failure diagnosed in the (Department of Nephrology of our hospital were randomly divided into two groups, 41cases in each group. The control group received routine clinical treatment such as hemodialysis.The observation group was treated with piperazine ferulate tablets and Astragalus injection for2 weeks.Observing the laboratory indicators and clinical efficacy before and after treatment in the two groups of patients. Results: Compared with the control group, the plasma endothelin,24h urine protein, BUN, Scr, Cys-C,β2 microglobulin and NGAL levels in the observation group were lower than those in the control group. The mortality of the observation group was significantly lower than that of the control group.(P<0.05).The hemoglobin and cure rate of the observation group were significantly higher than those of the control group (P<0.05). Conclusion: Piperazine ferulate tablets combined with Astragalus injection can effectively reduce β2 microglobulin and NGAL levels in patients with acute renal failure, improve renal function, improve cure rate and reduce mortality.