摘要
以表面接枝聚乙二醇链的聚酰胺胺树枝状聚合物(PEG-PAMAM)为纳米载体,在其内部空腔包覆金纳米粒子,在金纳米粒子表面连接硫辛酸改性的阿霉素(LA-DOX),从而间接实现了抗癌药物在PEGPAMAM内的高效负载.同时,LA-DOX中的酰腙键提供pH响应性,实现了药物的pH响应性释放.紫外-可见(UV-Vis)光谱表明,包覆金纳米粒子的PEG-PAMAM纳米载体对LA-DOX的负载能力显著增强.体外细胞实验表明,负载LA-DOX的树枝状聚合物-金纳米粒子复合药物载体具有较强的抗肿瘤能力.
Dendrimer-gold nanoparticle composites were prepared based on poly(ethylene glycol) modified dendrimer(PEG-PAMAM). Gold nanoparticles internal provided an efficient platform for lipoic acid functionalized DoxorubicinLA-DOX linking,leading to the high loading efficiency of anticancer drugs DOX. Meanwhile the hydrazine linker in LA-DOX realized pH sensitive release for nanocarrier. Verified by UV-Vis spectra,the loading efficiency of LA-DOX in dendrimer-gold nanoparticle nanocomposite was improved. Cell Experiment indicated excellent cytotoxicity of dendrimer-gold nanoparticle composite against Hela cells.
作者
朱钦富
胡可珍
李小杰
陈明清
.ZHU Qinfu;HU Kezhen;LI Xiaojie;CHEN Mingqing(Key Laboratory of Synthetic and Biological Colloid of the Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 2141221, China)
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2019年第5期1065-1070,共6页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:21504032)
中央高校基本科研业务费专项资金(批准号:JUSRP115A07)资助~~