替普瑞酮胶囊联合四联疗法治疗慢性萎缩性胃炎的疗效观察

Curative effect of teprenone capsule combined with quadruple therapy in the treatment of chronic atrophic gastritis

的探讨替普瑞酮胶囊联合四联疗法应用在慢性萎缩性胃炎患者中的临床疗效及应用价值方法回顾性分析2013年6月至2017年6月宁海县第一医院收治的慢性萎缩性胃炎患者150例的临床资料,根据治疗方案不同分为对照组和观察组,每组75例对照组患者釆用常规四联疗法,观察组联合替普瑞酮治疗,对比两组疗效;结果观察治疗总有效率为97.33%,高于对照组的85.33%,差异有统计学意义(χ^2=3.197,P<0.05)。观察组治疗后白细胞介素-8、肿瘤坏死因子-α分别为(7.04±1.03)ng/L、(41.02±1.72)ng/L,对照组治疗后分别为(10.81±1.63)ng/L、(57.35±2.95)ng/L,组间差异均有统计学意义(t=6.028、7.281,均P<0.05)。观察组治疗后胃黏膜评分、胃泌素浓度分别为(1.13±0.32)分、(8.97±2.33)pmol/L,对照组治疗后分别为(1.82±0.61)分、(5.36±1.52)pmol/L,组间差异均有统计学意义(t=5.661,6.024,均P<0.05)。结论替普瑞酮胶囊联合四联疗法应用在慢性萎缩性胃炎患者中能够提升临床疗效,减轻患者体内炎性反应程度,值得在临床推广应用.

Objective To analyze the curative effect of teprenone capsule combined with quadruple therapy in the treatment of chronic atrophic gastritis. Methods From June 2013 to June 2017 , one hundred and fifty patients with chronic atrophic gastritis admitted to the First Hospital of Ninghai County were retrospectively selected. According to different treatment schemes, they were divided into control group and observation group, with 75 patients in each group. The control group was treated with routine quadruple therapy, and the observation group was treated with teprenone capsule combined with quadruple therapy. The effective rate of the two groups was compared. Results The total effective rate of the observation group was 97. 33%, which was higher than 85. 33% of the control group, the difference between the two groups was statistically significant (χ^2=3. 197 , P < 0. 05 ). After treatment, the levels of interleukin - 8 and tumor necrosis factor - alpha in the observation group were ( 7. 04 ± 1. 03 ) ng/L,(41. 02 ± 1.72) ng/L,respectively, which in the control group were (10. 81 ± 1.63 ) ng/L,(57. 35 ± 2. 95 ) ng/L, respectively, the differences between the two groups were statistically significant (t = 6. 028,7. 281 , all P < 0. 05 ). The gastric mucosa score and the gastrin concentration in the observation group were (1.13 ±0. 32)points,(8. 97 ±2. 33)pmol/L, respectively,which in the control group were ( 1. 82 ± 0. 61 ) points,( 5. 36 ± 1. 52 ) pmol/L, respectively, the differences between the two groups were statistit ally significant (t = 5. 661,6. 024, all P < 0. 05 ). Conclusion Teprenone capsule combined with quadruple therapy can improve the clinical efficacy and reduce the degree of inflanirnation in patients with chronic atrophic gastritis, which is worthy of clinical application.