丝素蛋白材料在皮肤创伤愈合中的研究进展

Research Progress of Silk Fibroin Biomaterials in Skin Healing

丝素蛋白是一种天然的高分子纤维蛋白,其结构的特殊性决定了较好的机械性能,再因其优良的生物相容性、降解产物无毒等特点,被广泛用于各种材料的研究。通过各种化学修饰和负载生长因子等,使丝素蛋白在体内外具有促进成纤维细胞增殖分化的作用,拥有诱导创面愈合的功能,同时其可部分降解,具有缓释性能好,柔韧性强,透气以及透水等较好的理化性质不但在皮肤组织工程学中的广泛的应用,并且在敷料领域的研究也显示了其治疗烧烫伤、创伤达到抑制疤痕、促进伤口快速愈合的治疗效果。总之,通过改良丝素蛋白材料的加工方法,通过化学修饰、其他物质复合等手段得到适合于皮肤修复的具有优良性能的各种材料,是具有很大潜力的极具临床价值的皮肤修复材料。本文旨在综述国内及国外学者的各种关于丝素蛋白生物材料治疗皮肤损伤的研究最新进展。

Silk fibroin is a natural protein fiber,its unique structure determines the better mechanical properties,due to its excellent biocompatibility,non-toxic degradation products and other characteristics,are widely used in various materials research.Through a variety of chemical modification and load growth factors,the silk fibroin can promote fibroblast proliferation and differentiation in vitro or in vivo,has induced wound healing function,at the same time it can be partially degraded,with sustained good performance,strong flexibility,physicochemical properties and ventilation pervious better not only in skin tissue engineering the wide application and research in the field of dressing also shows its treatment of burns,wounds to inhibit scar and promote wound healing treatment.In a word,processing method of Fibroin Materials Modified by silk,chemical modification and other material means for a variety of materials with excellent properties in skin repair,skin repair materials for clinical value has great potential in the very.The purpose of this paper is to review the recent progress in the research of silk fibroin biomaterials in the treatment of skin injury.