The role and mechanism of regulatory T cells in indirect acute lung injury

Objective To study the role and mechanism of CD4^+ CD25^+ FoxP3^+ regulatory T cells ( Tregs) in the pathophysiological process of indirect acute lung injury (iALI) in mice. Methods The iALI model was successfully induced by shock/cecal ligation and puncture method. Sham (n = 8 ), cecal ligation and puncture (CLP,n=10), and hemorrhage (Hem, n=12) groups were established as controls.