2019096 Mutation analysis of SLC5A2 gene and determination of the renal threshold for glucose excretion in Chinese patients with familial renal glucosuria

Objective To analyze and identify the mutations in SGLT2 gene of nine Chinese families with FRG,and determine the renal threshold for glucose excretion (RTG),so as to explore the association of genotype and RTG.Methods All coding regions of SGLT2 gene,including intron exon boundaries,were analyzed using PCR followed by direct sequence analysis.