川芎嗪注射液联合利伐沙班对股骨颈骨折经髋关节置换术后下肢深静脉血栓形成的预防作用及对患者D-二聚体、IL-6、IL-10水平的影响

Effect of chuanxiongqin injection in combination with rivaroxaban in the prevention of deep venous thrombosis of lower extremity after operation of hip replacement and its influences on levels of D-Dimer,IL-6 and IL-10

目的探讨川芎嗪注射液联合利伐沙班对股骨颈骨折经髋关节置换术后下肢深静脉血栓形成(DVT)的预防作用及对患者D-二聚体、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)水平的影响。方法 2017年1月—2018年10月宜昌市第一人民医院收治120例股骨颈骨折并行髋关节置换术,随机分为利伐沙班组和川芎嗪注射液联合利伐沙班组,每组各60例。利伐沙班组中男性35例,女性25例;年龄46～76岁,平均66.7岁。川芎嗪注射液联合利伐沙班组中男性32例,女性28例,年龄44～74岁,平均66.1岁。术后,常规基础上,利伐沙班组给予利伐沙班治疗,川芎嗪注射液联合利伐沙班组给予川芎嗪注射液联合利伐沙班治疗。比较两组患者下肢DVT发生率、血浆D-二聚体水平、血清IL-6、IL-10等炎性因子水平及不良反应发生情况。结果术后2周,川芎嗪注射液联合利伐沙班组患者下肢DVT发生率低于利伐沙班组(6.7%vs. 20.0%,P<0.05)。术后2周,与利伐沙班组相比,川芎嗪注射液联合利伐沙班组患者血浆D-二聚体、血清IL-6水平降低,血清IL-10水平升高,组间比较差异有统计学意义(P均<0.05)。药物应用过程中,两组患者不良反应发生率组间比较差异无统计学意义(13.3%vs. 16.7%,P>0.05)。结论川芎嗪注射液联合利伐沙班能够有效预防股骨颈骨折患者经髋关节置换术后下肢DVT发生,明显降低术后血浆D-二聚体水平,改善相关炎性因子水平,且不增加不良反应发生率,临床上值得应用。

Objective To investigate the prevention effect of chuanxiongqin injection in combination with rivaroxaban in the prevention of deep venous thrombosis(DVT) of lower extremity after operation of hip replacement and its influences on levels of D-Dimer,interleukin 6(IL-6) and interleukin 10( IL-10). Methods Totally 120 patients who received hip replacement were collected as observational objects and randomly divided into the control group and the observation group with 60 cases in each group. In the obsevation group,there were 35 males and 25 females aged 66.7(46-76) years. In the control group,there were 32 males and 28 females aged 66.1(44-74) years.After operation,besides conventional treatments,the control group was given rivaroxaban,while the observation group was given chuanxiongqin injection in combination with rivaroxaban. Incidences of DVT of lower extremity,levels of plasma D-Dimer,serum inflammatory factors of IL-6,IL-10 and adverse reactions were compared between the two groups. Results Two weeks after operation,the incidence of DVT of lower extremity in the observation group was statistically lower than that in the control group(6.7% vs. 20.0%,P<0.05). Two weeks after operation,in comparison with the control group,the observation group had lower levels of plasma D-Dimer,serum IL-6 and higher level of serum IL-10 with all statistical differences(all P<0.05). During the application of drugs,the incidences of adverse reactions in the control group and the observation group were statistically same(13.3% vs. 16.7%,P>0.05). Conclusion Chuanxiongqin injection in combination with rivaroxaban can effectively prevent the incidence of DVT of lower extremity after hip replacement. And it can significantly reduce level of plasma D-Dimer and improve levels of related inflammatory factors without increasing incidence of adverse reactions.