基于疾病微环境靶向的精准纳米靶向技术研究

Precise nano-targeted technology based on disease microenvironment targeting

随着"精准医疗"概念的提出,治疗和诊断药物的精准靶向递送研究也成了纳米医学研究的前沿课题,并进入"精准"靶向纳米递药系统设计时代。针对危害人类健康的疾病的病灶特征,设计靶向特定病灶部位的纳米载药系统是重要策略之一,它可以改变药物在体内的分布,特异性增加靶部位的药物浓度,减少非靶部位的浓度,达到增强药效,降低不良反应,实现疾病的精准纳米靶向治疗。文章主要介绍近年来,基于肿瘤、AS以及炎症等疾病的病灶局部微环境特点,进行被动和主动纳米靶向药物递送系统的设计原理和最新研究进展,旨在为更多针对肿瘤及其他疾病的纳米精准递送系统的设计提供参考和依据。

Research into the rational delivery and targeting of pharmaceutical,therapeutic,and diagnostic agents is at the forefront of projects in nanomedicine with the launch of‘precision medicine’,and into the era of‘precise’targeted nano drug delivery system design. According to the lesion feature of disease endangering human health,it is one of the important strategies to design nano drug delivery system that targets each of the lesions which could change the distribution of drugs in the body,specifically increasing the concentration of drugs in the target sites and reducing the concentration of non-target sites,so as to enhance the efficacy,reduce adverse reactions and achieve precise nano-targeted treatment of diseases.at last. This article introduces the design principle and latest research progress of drug passive and active nano targeting delivery of drugs based on local microenvironment characteristics of lesions in tumors,atherosclerosis,inflammatory diseases in recent years,aiming to provide reference and basis for the design of more nano-targeted drug delivery systems for tumors and other diseases.