局部晚期鼻咽癌患者血清超氧化物歧化酶水平与诱导化疗疗效的关系分析

Relationship Between Short-term Efficacy of Inductive Chemotherapy and Serum Superoxide Dismutase Level in the Patients with Local Advanced Nasopharyngeal Carcinoma

目的 探讨局部晚期鼻咽癌患者血清超氧化物歧化酶(SOD)水平对诱导化疗疗效的影响。方法 选取确诊的局部晚期鼻咽癌患者60例,根据血清SOD水平由高到低均分为2组:A组、B组。2组患者均接受2周期DP方案或TPF方案诱导化疗,2~3周后复查,并行局部放疗。结果 诱导化疗后来院复查率100.00%。A组有效率为73.33%,B组有效率为83.33%,差异无统计学意义(χ^2=0.884,P=0.347)。A组恶心、呕吐发生率分别为46.67%、40.00%,低于B组的80.00%、73.33%(χ^2=7.177,P=0.007;χ^2=6.787,P=0.009);A组白细胞减少发生率为60.00%,低于B组的86.67%(χ^2=5.455,P=0.020)。结论 高血清SOD水平与局部晚鼻咽癌患者诱导化疗近期疗效无明显关系,但明显提高化疗的耐受性。

Objective To investigate the effect of serum superoxide dismutase(SOD) level on the short-term efficacy of inductive chemotherapy in patients with local advanced nasopharyngeal carcinoma. Methods A total of 60 patients with stage Ⅲ-Ⅳa nasopharyngeal carcinoma were enrolled. According to the serum SOD levels, they were divided into two groups: 30 patients with high serum SOD level in group A and 30 patients with low serum SOD level in group B. Both the groups received two cycle of DP regimen or TPF regimen inductive chemotherapy. After 2-3 weeks, the follow-up and the local radiotherapy were performed. Results The rate of re-examination was 100.00% after inductive chemotherapy. The response rate of the group A was 73.33%, and was 83.33% of the group B (χ^ 2= 0.884, P =0.347). The nausea and vomiting incidences in the group A (46.67% and 40.00%) were significantly lower than those in the group B (80.00%, 73.33%;χ^ 2=7.177, P =0.007;χ^2=6.787, P = 0.009 ). The incidence of leukopenia in the group A (60.00%) was lower than it in the group B (86.67%;χ^ 2=5.455, P = 0.020 ). Conclusion High serum SOD level has no significant effect on the local control rate of patients with local advanced nasopharyngeal carcinoma, but it can improve the tolerance of patients to chemotherapy.