7-脱甲氧基娃儿藤碱(DEM)镇痛抗炎作用试验

Studies on Ache Easing and Anti-inflammafory Effect of 7-Demethoxylophorine

[方法]研究以小鼠为实验动物,用热板法研究不同浓度的7-脱甲氧基娃儿藤碱(DEM)对小鼠的镇痛作用。以二甲苯所致小鼠耳壳肿胀作用为模型,对不同浓度DEM注射剂的抗炎作用进行了研究。[结果]结果表明,30 mg/kg体重的DEM对热板法所致小鼠的疼痛反应具有明显的抑制作用;最小剂量在0.50 mg/kg时对二甲苯所致小鼠的耳壳肿胀有明显的抑制作用(P<0.01),作用与剂量呈正相关性。

[Method] Studying on ache easing effect from different concentrations 7-Demethoxylophorine with hot plate, and choosing different concentrations 7-Demethoxylophorine injectables researching anti-inflammafory effect.[Result] The results showed 50 mg/kg weight have clear restraint ache of mice;the smallest dose of 7-Demethoxylophorine in 0.50 mg/kg had obvious inhibition effect to ears swelling of mice by xylene C6H4(CH3)2(P<0.01), the effect and dose was positive relevant.