幽门螺杆菌与炎性肠病相关性及其可能机制的研究进展

Research Progress in Correlation between Helicobacter Pylori and Inflammatory Bowel Disease and Its Possible Mechanism

炎性肠病是一种慢性非特异性的肠道炎性疾病,目前认为其是遗传、免疫、肠道微生物及环境等多种因素共同作用的结果。幽门螺杆菌作为胃肠道常见的感染菌,与多种自身免疫性疾病(如过敏反应、哮喘等)密切相关。鉴于炎性肠病致病因素既涉及肠道微生物,又涉及免疫,因此,幽门螺杆菌与炎性肠病的相关性以及产生相关性的机制即得到学界的高度关注,针对幽门螺杆菌与炎性肠病的关系目前研究结果并不一致,产生相关性的机制的探讨也在不断深入。

Inflammatory bowel disease is a chronic nonspecific inflammatory bowel disease,which is considered to result from a combination of genetic,immune,intestinal microbiota and environmental factors.Helicobacter pylori,as a common infective bacterium in gastrointestinal tract,is closely associated with many autoimmune diseases,such as allergy,asthma.In view of the fact that the pathogenic factors of inflammatory bowel disease involve both intestinal microbiota and immunity,the relationship between Helicobacter pylori and inflammatory bowel disease and the mechanism of the correlation have been highly concerned in academic circles.At present,the research results on the relationship between Helicobacter pylori and inflammatory bowel disease are not consistent,and the study about the mechanism of the correlation is also getting deeper and deeper.