摘要
右美托咪定是一种高选择性α_2肾上腺素能受体激动剂,其通过作用于脑干蓝斑核内的α_2肾上腺素受体,产生类似自然睡眠状态的镇静、镇痛效果。近年来,右美托咪定的器官保护作用逐渐受到人们的关注,它可以通过减少去甲肾上腺素释放,抑制炎性因子生成,减少应激所致机体损伤;减少氧化应激反应所致促炎性因子生成,保护脏器功能;作用于神经传导通路,减少细胞凋亡,发挥器官保护作用。但未来仍需对右美托咪定的器官保护作用进行更广泛的研究。
Dexmedetomidine is a highly selective α2 adrenergic receptor agonist,which produces sedative and analgesic effect similar to natural sleep by acting on α2 adrenergic receptors in locus coeruleus nucleus of brain stem.In recent years,the organ protection effect of dexmedetomidine has gradually attracted people’s attention.It can reduce the release of norepinephrine,inhibit the production of inflammatory factors,and reduce the body damage caused by stress;reduce the generation of pro-inflammatory factors caused by oxidative stress,protect the function of organs;act on nerve conduction pathway,reduce cell apoptosis,playing the role of organ protection.However,more extensive studies on the organ protection of dexmedetomidine are still needed in the future.
作者
王琴
王辉
WANG Qin;WANG Hui(Department of Anesthesiology,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《医学综述》
2019年第9期1822-1826,共5页
Medical Recapitulate
