摘要
脓毒症感染诱发的全身炎症反应可导致机体分解代谢亢进、氨基酸稳态失衡、低蛋白血症,继而出现营养状态、免疫功能和重要器官功能恶化,增加了脓毒症患者的死亡风险。研究脓毒症患者体内重要氨基酸的生理作用和代谢变化,寻找更快速、更准确的氨基酸检测方法,从而及时发现、纠正脓毒症患者体内氨基酸代谢紊乱,将有助于为脓毒症患者提供更精准的个体化营养支持治疗方案,降低其病死率和并发症发生率。
Sepsis caused systemic inflammatory response may result in hypermetabolism,imbalance of amino acid homeostasis and hypoproteinemia,which can lead to deterioration of nutritional status,immune function and important organ function,and accelerate the death of the septic patients.To study the physiological function and metabolic changes of important amino acids in the septic patients and find a more rapid and accurate method for amino acid detection,so as to detect and correct the metabolic disorders of amino acids in time,will help to implement more accurate individual nutritional support treatment for the septic patients,and reduce the complications and mortality.
作者
熊梓宏
张国英
任兴琼
张宁
周芹
卢宾
XIONG Zihong;ZHANG Guoying;REN Xingqiong;ZHANG Ning;ZHOU Qin;LU Bin(Pediatric Intensive Care Unit,Chengdu Women and Children′s Central Hospital,Chengdu 610091,China)
出处
《医学综述》
2019年第9期1851-1855,共5页
Medical Recapitulate
关键词
脓毒症
氨基酸
代谢变化
检测方法
Sepsis
Amino acid
Metabolic change
Analysis methods