脓毒症氨基酸代谢变化及检测方法的研究进展

Research Progress of Amino Acid Metabolism and Analysis Methods in Sepsis

脓毒症感染诱发的全身炎症反应可导致机体分解代谢亢进、氨基酸稳态失衡、低蛋白血症,继而出现营养状态、免疫功能和重要器官功能恶化,增加了脓毒症患者的死亡风险。研究脓毒症患者体内重要氨基酸的生理作用和代谢变化,寻找更快速、更准确的氨基酸检测方法,从而及时发现、纠正脓毒症患者体内氨基酸代谢紊乱,将有助于为脓毒症患者提供更精准的个体化营养支持治疗方案,降低其病死率和并发症发生率。

Sepsis caused systemic inflammatory response may result in hypermetabolism,imbalance of amino acid homeostasis and hypoproteinemia,which can lead to deterioration of nutritional status,immune function and important organ function,and accelerate the death of the septic patients.To study the physiological function and metabolic changes of important amino acids in the septic patients and find a more rapid and accurate method for amino acid detection,so as to detect and correct the metabolic disorders of amino acids in time,will help to implement more accurate individual nutritional support treatment for the septic patients,and reduce the complications and mortality.