环境中抗生素抗性基因及消减途径研究

Antibiotic resistance genes and approaches for reducing their abundance in environments

自抗生素发现以来,在挽救了无数生命的同时,也带来了严重的环境问题。在我国,由于多年来抗生素的使用处于监管失控状态,大量的抗生素随人和动物粪便等排泄物流入环境,导致抗生素引起的环境污染问题越发严重。本文针对抗生素抗性基因这一新型环境污染物,综述了环境中抗生素抗性基因的种类、来源、分布状况、传播途径和生态风险,重点阐述了消减抗生素抗性基因的技术途径,并结合目前抗生素抗性基因污染状况,对今后研究重点进行了展望。

Antibiotics saved countless lives but also caused serious environmental problems since they were discovered.In China,due to the uncontrolled use of antibiotics for a long time,a huge amount of antibiotics has flown into the environments along with human and animal excreta,which leads to additional environmental pollution.Antibiotic resistance genes (ARGs)has been considered as a new type of environmental pollutants.In this paper,we summarized the types,sources,distribution,dissemination and ecological risks of ARGs in environment.In addition,the technical approaches of how to reduce the abundance of antibiotic resistance genes were highlighted,and the future research avenues were prospected.