乳化体系对薰衣草香料液体纳米胶囊形成能力的影响

Effects of emulsifying systems on preparation of lavender flavor liquid nanocapsules

本文以壳聚糖为壁材、以薰衣草香料为芯材,考察了乳化体系对薰衣草香料液体纳米胶囊形成能力的影响.本文所选用的乳化剂包括:Tween-20、Tween-40、Tween-60、Tween-80、Tween-85、CO-40及Span-80.首先,分别以Tween-20、Tween-40、Tween-60、Tween-80、Tween-85及CO-40为乳化剂制备薰衣草香料液体纳米胶囊并绘制相关伪三元相图,考察了乳化剂结构对液体纳米胶囊形成能力的影响.随后将Tween-60与Span-80复配,考察乳化体系的亲水亲油平衡值(HLB值)对液体纳米胶囊形成能力的影响.另外还考察了三种助乳化剂:乙醇、1,2-丙二醇及正丁醇以及乳化剂与助乳化剂质量比(Km值)对液体纳米胶囊形成能力的影响.最后,借助动态光散射技术(DLS)、电导率等表征手段,研究了乳化体系与芯材的质量比(S:O)对所制备的薰衣草香料纳米胶囊的粒径及其粒径分布、透光率以及结构类型的影响.结果表明,以CO-40与Span-80复配作为乳化剂, 1,2-丙二醇为助乳化剂, Km值为3, S:O值大于7:3时,可以制得可无限稀释的粒径约为10 nm、低分散且透明的薰衣草香料液体纳米胶囊.

Herein, the influences of commercial emulsifying systems properties on the performance of the lavender flavor liquid nanocapsules are studied by using chitosan as the wall material and the lavender flavor as the core material,and seven commercial emulsifiers: Tween-20, Tween-40, Tween-60, Tween-80, Tween-85, Span-80 and CO-40, are chosen to constitute the emulsifying systems. Firstly, lavender flavor nanocapsules are prepared with different emulsifiers and the corresponding pseudo-ternary phase diagrams are drawn to illustrate the effects of structures of emulsifier on performances of liquid nanocapsules. Meanwhile, nanocapsules are also prepared with emulsifying systems of different HLB values, the results show that, nanocapsules can be formed easily when the HLB value of emulsifying systems matching up with the RHLB value of lavender flavor. Finally the effect of structures of coemulsifier and the values of Kmon performance of nanocapsules are also investgated. The results show that, by using CO-40 and Span-80 as emulsifiers, 1,2-propylene glycol as a co-emulsifier, when Kmequals to 3 and S/O value is greater than 7:3, the obtained lavender flavor liquid nanocapsules are transparency, which have a diameter of about 10 nm with low dispersion.