分泌型卷曲相关蛋白1在心血管疾病中的研究进展

Present state of research on sFRP-1 in relation to cardiovascular disease

分泌型卷曲相关蛋白1(sFRP-1)基因实质为一种分泌型糖蛋白,主要与Wnt信号通路具有同源结构的卷曲蛋白受体竞争性结合,通过对Wnt信号通路的负调控,广泛介入到调控细胞增殖、分化、凋亡、癌变以及调节机体的生长发育、疾病等病理生理的复杂过程.抑制Wnt信号通路可以阻止心肌细胞缺血坏死面积的进一步扩大,延缓心肌重塑的过程,进而改善预后.作为Wnt信号通路的抑制因子,sFRP-1的作用不可忽视.相关实验研究结果表明,sFRP-1基因很有可能成为未来心血管疾病治疗的靶向基因.

The sFRP-1 gene, in essence, is a secretory glycoprotein, which plays a negative regulatory role in the Wnt signaling pathway by competitively binding to frizzled protein receptors with homologous structures in the Wnt signaling pathway. By negatively regulating the Wnt signaling pathway, it is widely involved in the complex pathophysiological processes of regulating cell proliferation. differentiation, apoptosis, carcinogenesis, growth, development and disease of the body. Inhibition of Wnt signaling pathway can prevent further expansion of infarct area of myocardial cells, delay the process of myocardial remodeling and thereby improve the prognosis. As an inhibiting factor of Wnt signaling pathway, the role of sFRP-1 cannot be neglected and the results of related experimental studies show that sFRP-1 gene is likely to become a target gene for future cardiovascular disease treatment.