microRNA和lncRNA在银屑病中的研究进展

MicroRNAs and lncRNAs in psoriasis

银屑病是一种常见的慢性炎症性皮肤病,目前普遍认为该病是在多基因遗传背景下主要由T细胞介导的免疫异常性疾病。近年研究发现,microRNA和lncRNA能够参与多种炎症免疫性疾病的发生发展过程。已证实microRNA和lncRNA能够通过调控角质形成细胞增殖与分化、炎症因子释放以及血管形成等功能参与银屑病的发病过程。本文综述microRNA和lncRNA在银屑病中的研究进展。

Psoriasis is a common chronic inflammatory skin disease,and commonly considered as a T cell-mediated abnormal immune disease with genetic predisposition at present.Recent studies have indicated that microRNAs and lncRNAs play important roles in occurrence and development of a variety of inflammatory immune diseases.It has been confirmed that microRNAs and lncRNAs participate in the occurrence of psoriasis by regulating the proliferation and differentiation of keratinocytes,release of inflammatory factors,and angiopoiesis.This review summarizes research advances in roles of microRNAs and lncRNAs in psoriasis.