肠道菌群与银屑病关系的研究进展

Relationship between intestinal flora and psoriasis

银屑病是一种慢性炎症性复发性皮肤病,发病机制至今尚未完全清楚,目前认为免疫、遗传及环境因素在其发病中起重要作用。越来越多研究证明,肠道菌群失调与免疫疾病有关,尤其与炎症性肠病关系密切。而银屑病与炎症性肠病发病机制及临床表现上有众多相似之处,肠道微生物群变化也被证实与银屑病有关。本文就银屑病与肠道菌群失调之间的可能关联展开讨论。

Psoriasis is a chronic recurrent inflammatory skin disease,and its pathogenesis is still unclear.At present,it is believed that immune,genetic and environmental factors play important roles in the occurrence of psoriasis.More and more studies have indicated that the imbalance of intestinal flora is associated with immune diseases,especially inflammatory bowel disease.The pathogenesis and clinical manifestations of psoriasis are similar to those of inflammatory bowel disease,and psoriasis is proved to be associated with changes in intestinal microbial flora.This review discusses the association between the imbalance of intestinal flora and psoriasis.