顶复门原虫蛋白质泛素化修饰的研究进展

Advances in ubiquitination modification of apicomplexa protozoans

顶复门原虫是一类细胞内专性寄生原虫,其生命周期复杂,且不同阶段具有不同的生物学形态。基于其多变且复杂的生命周期,顶复门原虫通过不同的蛋白质翻译后修饰(PTM)调节细胞进程。泛素化是一种常见的PTM,蛋白质泛素化在蛋白质周转代谢、细胞信号传导和细胞内转运等过程中起关键作用。本文综述了顶复门原虫重要细胞器的泛素化修饰,以期了解泛素化修饰对顶复门原虫细胞周期的影响。

Apicomplexa phylum is a family of specific intracellular parasitic protozoans that undergo complex life cycles involving multiple developmental stages with distinct morphologies.Post-translational modification (PTM) occur throughout the complex life cycle of apicomplexan to regulate cellular processes and play roles in all aspects of cytobiology.Ubiquitination is a common modification in PTM.Protein ubiquitination plays a key role in protein turnover,cell signaling and intracellular transport.In this review,we summarize the ubiquitination modification of important organelles in apicomplexa protozoans to better understand the effect of ubiquitination on the cell cycle and functions of apicomplexan.