睡眠障碍合并抑郁症患者的认知功能情况及其影响因素分析

Study on Cognitive Impairment and Influencing Factors in Patients with Sleep Disorders and Depression

【目的】探讨睡眠障碍合并抑郁症患者的认知功能情况及其影响因素。【方法】选取2014年11月至2016年9月本院确诊的160例睡眠障碍患者,其中60例合并抑郁症(A组)、单纯睡眠障碍100例(B组),采用重复性成套神经心理状态测验(RBANS)评估两组患者的认知功能,并采用多因素回归分析方法分析患者认知功能障碍的相关因素。[结果]A组患者的即刻记忆、视觉广度、言语功能、注意力、延时记忆、RBANS总分均显著低于B组,其差异均有统计学意义(P<0.05);A组患者认知功能障碍检出率为46.67%(28/60),显著高于B组患者的7.00%(7/100),其差异具有统计学意义(P<0.05);颈动脉狭窄、睡眠障碍病程延长、合并抑郁症是睡眠障碍患者并发认知功能障碍的独立危险因素(OR=2.296、OR=1.574、OR=1.309,P<0.05)。【结论】睡眠障碍合并抑郁症患者其认知功能障碎检出率显著增加,颈动脉狭窄、睡眠障碍病程延长、合并抑郁症是睡眠障碍患者并发认知功能障碍的独立危险因素,临床士应依据其危险因素采用相应的措施加以防范。

【Objective】To investigate the cognitive impairment and influencing factors in patients with sleep disorders and depression.【Methods】A total of 160 patients with sleep disorders in our hospital from No-vember 2014 to September 2016 were enrolled in this study.Among them,60 patients with depression were treated as group A and 100 patients with simple sleep disorder as group B.Tests with repetitive neuropsychological status(RBANS)were used to evaluate the cognitive function of the two groups.The factors related to the cognitive impairment were explored by multivariate regression analysis method.【Results】The immediate memory,breadth of vision,speech function,attention,time-delayed memory and the total score of RBANS in group A were significantly lower than those in group B.the differences were statistically significant(P<0.05).The detection rate of cognitive impairment in group A was 46.67%(28/60),which was significantly higher than that in group B 7%(7/100).The difference was statistically significant(P<0.05).Carotid stenosis*prolonged course of sleep disorders and depression were independent risk factors for cognitive dysfunction in patients with sleep disorders(OR=2.296,OR=l.574,0R=1.309,P<10.05).【Conclusion】Carotid steno-sis?prolonged course of sleep disorders and depression are independent risk factors for cognitive dysfunction in patients with sleep disorders.Sleep disorders associated with depression will further increase the cognitive impairment of patients,so we must pay attention to the treatment of patients with depression.