血尿酸水平和N端前脑钠肽与原发性高血压的相关性研究

Relationship between serum uric acid level, N terminal pro-brain natriuretic peptide and essential hypertension

目的:探讨血尿酸水平和N端前脑钠肽(NT-proBNP)与原发性高血压的相关性。方法:回顾性分析选取原发性高血压患者分为高血压1级组32例、高血压2级组50例、高血压3级组41例,另选同期健康体检者120名作为对照组。所有研究对象进行血脂、血糖、血尿酸、NT-proBNP检测并比较检测结果。结果:高血压各组的血尿酸和NT-proBNP水平均高于对照组,差异具有统计学意义(P<0.05);高血压3级组血尿酸和NT-proBNP水平均高于高血压2级组和高血压1级组,差异具有统计学意义(P<0.05);高血压2级组NT-proBNP水平高于高血压1级组,差异均有统计学意义(P<0.05)。血尿酸水平与高血压呈正相关(r=0.105,P<0.05),NT-proBNP水平与高血压呈正相关(r=0.119,P<0.05)。血尿酸、NT-proBNP水平为高血压的独立危险因素(OR=1458,95%CI 1.001.1.048;OR=1.316,95%CI1.044-1.068),且随血压水平的升高而增大。结论:血尿酸和NT-proBNP水平为高血压的独立危险因素,且与高血压呈正相关,同时检测血尿酸和NT-proBNP水平能够为临床高血压的预测与干预治疗提供重要依据。

Objective: To discuss the relationship between serum uric acid level, N terminal pro -brain natriuretic peptide (NTproBNP) and essential hypertension. Methods: Patients with essential hypertension were divided into 32 cases as hypertension group one, 50 cases as hypertension group two and 41 cases as hypertension group three and analysed retrospectively. 120 health examiners in the same period were selected as the control group. Blood lipids, blood sugar, uric and and NT-proBNP of all subjects were detected and compared. Results: The serum uric acid and NT -proBNP water in hypertension groups were higher than those in the control group and the difierences were statistically significant (P<0.05). The levels of serum uric acid and NT-proBNP in hypertension group three were higher than those in hypertension group one and two and the differences were statistically significant (P<0.05). The level of NT-proBNP in the hypertension group two was higher than that in the hypertension group one and the difference was statistically significant (P<0.05). Serum uric acid level was positively correlated with hypertension (r = 0.105, P<0.05) while NT-proBNP level was positively correlated (r = 0.119, P<0.05). The levels of blood uric acid and NT-proBNP were independent risk factors of hypertension (OR=1.458, 95%CI 1.001-1.048;OR=1.316, 95%CI 1.044-1.068) and increased with blood pressure. Conclusion: Serum uric acid and NT-proBNP levels are independent risk factors for hypertension and so positively correlated with hypertension that can provide important evidence for the prediction and intervention of clinical hypertension.