肿瘤相关中性粒细胞对恶性肿瘤生物学特性的影响及机制研究

Study on the influence of tumor-associated neutrophils on the biological characteristics of malignant tumors and its mechanism

恶性肿瘤的发生、发展与肿瘤的微环境密切相关。肿瘤相关中性粒细胞(TAN)是肿瘤微环境中重要的炎性细胞。研究证实,TAN在肿瘤生长、侵袭、转移、病理性血管生成以及免疫逃逸过程中发挥重要的作用。TAN可被活化为抗肿瘤作用的N1型和促肿瘤效应的N2型。文章就TAN的生物学特性以及TAN在恶性肿瘤中的作用及其机制进行综述。

The occurrence and development of malignant tumors is closely related to the tumor microenvironment. Tumor-associated neutrophils (TAN) are important inflammatory cells in the tumor microenvironment. Studies have confirmed that TAN plays an important role in tumor growth, invasion, metastasis, pathological angiogenesis, and immunity escapes. TAN can be activated as an anti-tumor N1 type and a tumor-promoting N2 type. This article reviews the biological characteristics of TAN and the role of TAN in the malignant tumors and its mechanism.