摘要
红细胞衰亡(eryptosis)是指成熟红细胞在各种因素刺激下发生的自杀性程序性死亡,表现为膜内侧的磷脂酰丝氨酸(phosphatidylserine, PS)外翻、细胞皱缩体积变小以及细胞膜囊泡化等。衰亡红细胞由于PS外翻暴露而被巨噬细胞表面的PS受体识别,进而被吞噬并降解。肝脏是清除衰亡红细胞的主要器官,深入研究红细胞衰亡及其在肝脏中的识别与清除机制,有助于明确红细胞衰亡在肝脏疾病中的作用及病理生理学意义。
Erythrocytes undergo programmed cell death, similar to apoptosis, known as eryptosis. Eryptosis results from a wide variety of contributors and is characterized by phosphatidylserine (PS) exposure, cell shrinkage, and the presence of membrane blebbing. Erythrocytes with PS exposure are bound to and engulfed by macrophages in a PS-dependent manner. The liver as the primary organ supports rapid erythrocyte removal. Research on molecular mechanisms dictating eryptosis would help reveal the physiological and pathological significance of eryptosis in liver.
作者
徐薇
彭芳
李宁
XU Wei;PENG Fang;LI Ning(Department of Blood Transfusion, Xiangya Hospital,Central South University, Changsha 410008,Hunan, China;Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital,Central South University, Changsha 410008,Hunan, China)
出处
《生命科学研究》
CAS
CSCD
2019年第2期135-139,共5页
Life Science Research
基金
国家自然科学基金资助项目(81873574)
