替加环素致精神行为异常

Mental and behavioral disorders due to tigecycline

1例77岁男性患者因慢性阻塞性肺疾病急性加重、药物敏感试验显示致病菌对替加环素敏感,给予替加环素100 mg静脉滴注,用药后约3 h出现幻觉、胡言乱语等精神行为异常表现。次日停用替加环素,患者意识好转、对答切题。因感染控制不佳,6 d后再次静脉滴注替加环素50 mg,用药后约8 h,患者出现睁眼凝视某处、呼之不应等精神行为异常表现。停用替加环素后,患者意识恢复。

A 77-year-old male patient received an IV infusion of tigecycline 100 mg for the acute exacerbation of chronic obstructive pulmonary disease and the flora species being sensitive to tigecycline in his antibiotic sensitivity test. About 3 hours after the infusion, the patient developed mental and behavioral abnormalities such as hallucinations and balderdash. Tigecycline was stopped the next day, and the patient′s consciousness improved and he could answer questions correctly. Because of the poor control of the infection, an IV infusion of tigecycline 50 mg was given 6 days later. About 8 hours after the infusion, the patient developed mental and behavioral abnormalities such as staring at a certain place and unresponsiveness to verbal stimuli. Then tigecycline was stopped, and the patient′s consciousness recovered.