阿司匹林过量致耳聋和全血细胞减少

Deafness and pancytopenia induced by overdose of aspirin

1例69岁女性患者因记忆混乱,误服大剂量阿司匹林肠溶片(4.86 g、2次/d)。服药3次后出现听力下降;服药7次时(累积服药剂量达34.02 g)被家属发现后停药并送至医院。听力测试提示为感音神经性耳聋,实验室检查发现全血细胞减少,白细胞计数最低1.9×109/L,红细胞计数最低3.0×1012/L,血红蛋白最低99 g/L,血小板计数最低39×109/L。给予补液和对症治疗。18 d后患者听力恢复正常,白细胞计数8.4×109/L,红细胞计数3.7×1012/L,血红蛋白123 g/L,血小板计数113×109/L。

A 69-year-old female patient mistakenly took overdose of aspirin enteric-coated tablets (4.86 g, twice daily) because of memory confusion. After taking 3 times of aspirin overdose, she developed hearing loss. When the medication was taken for the seventh time (the aspirin cumulative dosage was 34.02 g), the medication error was found by her relatives. The medication was discontinued and the patient was taken to the hospital. Hearing tests suggested the sensorineural deafness and laboratory tests revealed pancytopenia. The lowest white blood cell count(WBC) was 1.9×109/L, the lowest red blood cell count(RBC) was 3.0×1012/L, the lowest hemoglobin(Hb) was 99 g/L, and the lowest platelet count(PLT) was 39×109/L. After 18 days of rehydration and symptomatic treatments, her hearing recovered to normal. Laboratory tests showed WBC 8.4×109/L, RBC 3.7×1012/L, Hb 123 g/L, and PLT 113×109/L.