布洛芬前药研究进展

Research progress of ibuprofen prodrugs

布洛芬(IBU)是非甾体抗炎药中最常见和最具代表性的药物之一,临床应用非常广泛。布洛芬发生的临床常见不良反应是胃肠道反应,且半衰期短,给药量大,需频繁给药。布洛芬引起的胃肠刺激主要是游离羧基直接与胃肠道接触,因此,为了避免或减轻布洛芬的胃肠道不良反应,提高疗效和患者的顺应性,科研工作者对布洛芬前药进行了大量研究。本文参考大量文献,对近年来布洛芬前药的研究进行了综述。

Ibuprofen(IBU),one of the most common and representative drug among non-steroidal anti-inflammatory agents,is widely used in clinic.The major limitations of IBU are gastrointestinal reaction,a large dosage and a short half-life resulting in a frequent administration.Gastrointestinal stimulation of IBU is mainly caused by its free carboxyl directly interacting with the gastrointestinal tract,in order to avoid or mitigate its side effects,improve the curative effect and compliance of patients,researchers have done a lot of studies about ibuprofen prodrugs.Therefore,in this report,the research progress of ibuprofen prodrugs on the basis of a large number of literatures were reviewed.