儿童期虐待与成年后精神分裂症的相关性

Correlation between childhood abuse and adult schizophrenia

目的探讨儿童期虐待与成年后精神分裂症的相关性。方法使用北京安定医院精神疾病临床数据与生物样本库的受试者数据库(2142例),从中选取符合分析要求的健康对照(111例)和精神分裂症(82例)受试者,通过分析比较两组儿童期虐待问卷的数据,探讨儿童期虐待与成年后精神分裂症的关系。并将病例组按照发病次数分组(≤2次或>2次)后进行儿童期虐待问卷分数的比较。结果精神分裂症组和健康对照组之间儿童期虐待问卷总分及各分量表分数(情感虐待、躯体虐待、性虐待、情感忽视和躯体忽视)差异均有统计学意义(t’=-9.18、-10.58、-8.98、-7.39、-6.09、-7.89,均P<0.05)。精神分裂症组发作次数≤2次组与发作次数>2次组的儿童期虐待问卷总分及各分量表分数(情感虐待、躯体虐待、性虐待、情感忽视和躯体忽视)差异均有统计学意义(t’=13.29,13.22,7.77,8.60,12.59,9.33,均P<0.05)。结论精神分裂症的患者儿童期虐待问卷的分数值高于正常人群,并且发作次数多的虐待问卷分数高,提示成年后的精神分裂症患者可能存在儿童期受虐待的经历。

Objectives To discuss the correlation between childhood abuse and adult schizophrenia. Methods From the subject database of clinical data and biological sample library of mental illness in Beijing Anding Hospital( n=2 142), 82 schizophrenia subjects and 111 controls were selected. We discussed the relationship between childhood abuse and adult schizophrenia by analyzing and comparing the data from the two groups using the Childhood Trauma Questionnaire( CTQ). The schizophrenia group was first divided into two sub-groups according to the number of episodes(≤2 times or >2 times). The scores of CTQ in the two subgroups were compared. Results The differences in the total scores and dimension scores( i.e., emotional abuse, physical abuse, sexual abuse, emotional neglect and physical neglect) of the CTQ showed statistical significance across experimental and control groups( t’=-9.18,-10.58,-8.98,-7.39,-6.09,-7.89, all P< 0.05). The difference of total score and dimension score( emotional abuse, physical abuse, sexual abuse, emotional neglect and physical neglect) of the CTQ is also significant across the two sub-groups of the experimental group( t’=13.29, 13.22,7.77,8.60,12.59,9.33, all P < 0.05). Conclusions Schizophrenia patients score higher in CTQ than normal population and the score increases with the number of psychotic episodes, suggesting that adult schizophrenia patients may have histories of childhood abuse.