精神分裂症的脱髓鞘机制研究进展

Research progress of demyelination mechanism in schizophrenia

精神分裂症是一种以思维、知觉、情感和行为等多方面障碍为主要表现的常见精神疾病,其病理生理及病因过程错综复杂,其中脱髓鞘机制愈发受到人们的关注,通过了解精神分裂症脱髓鞘病变的机制有利于从根本上治疗和预防精神分裂症。现从少突胶质细胞、神经递质和神经炎症3个方面总结精神分裂症相关的脱髓鞘病变机制,探讨脱髓鞘对精神分裂症病理过程的影响,从而寻找新的治疗方向。

Schizophrenia is a common mental illnesses with aspects of obstacles such as thinking, perception, emotion and behavior. The physiological pathology and etiology process is complex, and demyelinating mechanism has attracted more and more attention. Understanding the mechanism of schizophrenia demyelinating lesions is conducive to the fundamental treatment and prevention of schizophrenia. This paper is a summary of the mechanism of schizophrenia-related demyelinating lesions from the three aspects of oligodendrocytes, neurotransmitter and neuroinflammation, so as to explore the influence of demyelination on the pathological process of schizophrenia and to find the new therapeutic direction.