S100A12与急性胰腺炎严重程度的相关性及其临床应用价值

Correlation between S100A12 level and the severity of acute pancreatitis and its clinical application value

目的研究S100A12与急性胰腺炎严重程度的关系及其临床应用价值。方法选取2013年9月至2017年9月铜仁市人民医院收治的81例急性胰腺炎患者,采用ELASA法测定患者血清S100A12水平,通过受试者工作特征曲线分析其与急性胰腺炎严重程度的关系。结果轻症急性胰腺炎组和重症急性胰腺炎组S100A12水平、C-反应蛋白(CRP)水平、Ranson评分、急性生理与慢性健康Ⅱ(APACHEⅡ)评分均高于对照组,差异有统计学意义(P<0.05);重症急性胰腺炎组血清S100A12水平、CRP水平、Ranson评分、APACHEⅡ评分均高于轻症急性胰腺炎组,差异有统计学意义(P<0.05)。结论通过受试者工作特征曲线下面积的95%置信区间对比发现,S100A12作为判断急性胰腺炎严重程度的敏感性和特异性均优于CRP水平、Ranson评分和APACHEⅡ评分。S100A12水平具有较好的临床应用价值,且优于目前常用评价手段。

Objective To study the relationship between S100A12 level and the severity of acute pancreatitis and its clinical application value. Methods Eighty-one patients with acute pancreatitis admitted to Tongren People’s Hospital from September 2013 to September 2017 were selected, and the serum S100A12 level of them was detected by enzyme linked immunosorbent assay (ELASA). The relationship between S100A12 level and the severity of acute pancreatitis was analyzed by receiver operating characteristic (ROC) curve. Results The serum S100A12 level, C reactive protein (CRP) levels, Ranson score and acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) score of mild acute pancreatitis group and severe acute pancreatitis group were higher than those of control group (P<0.05). The serum S100A12 level, CRP level, Ranson score and APACHE Ⅱ scores of severe acute pancreatitis group were significantly higher than those of mild acute pancreatitis group, and the difference was statistical significance (P<0.05). Conclusions By comparing the 95% confidence interval of the area under the ROC curve of the subjects, it is found that the sensitivity and specificity of S100A12 as a judgment of the severity of acute pancreatitis are better than CRP level, Ranson score and APACHE Ⅱ score. The level of S100A12 has good clinical application value, and it is superior to the commonly used evaluation methods at present.