人乳头瘤病毒分型检测与宫颈疫苗在宫颈癌防治中的应用

Application of human papillomavirus typing detection and cervical vaccine in prevention and treatment of cervical cancer

目的探究人乳头瘤病毒(HPV)分型检测与宫颈疫苗在宫颈癌防治中的应用。方法选取2017年1月至2017年12月惠州地区35~60岁1 450例育龄女性作为研究对象,根据病理组织学检测结果分为健康组、慢性宫颈炎组、宫颈上皮内瘤(CIN)Ⅰ组、CINⅡ组、CINⅢ组,均实施HPV分型检测,分析不同年龄段的HPV感染情况和不同级别宫颈病变中HPV的感染情况。结果共检测出352例HPV感染,HPV检出率为24.3%;年龄的增长与HPV感染呈正相关,年龄越大,HPV的感染率越高,不同年龄组HPV感染率比较差异有统计学意义(P<0.05);宫颈病变级别越高,HPV感染率越高,更强调对于有性生活的女性,定期接受子宫颈癌筛查具有重要的临床意义。不同宫颈病变级别间HPV感染率比较差异有统计学意义(P<0.05)。结论宫颈癌的筛查中,将HPV分型检测与宫颈疫苗联合应用,有利于筛查工作的顺利进行,可以为宫颈癌的防治提供重要的参考依据。

Objective To investigate the application value of typing detection of human papillomavirus (HPV) and cervical vaccine in the prevention and treatment of cervical cancer. Methods A total of 1 450 women aged 35-60 years old in Huizhou area from January 2017 to December 2017 were selected as research subjects. According to the histological examination, enrolled patients were divided into healthy group, chronic cervicitis group, cervical intraepithelial neoplasm (CIN)Ⅰ group, CIN Ⅱ group and CIN Ⅲ group. All patients underwent HPV typing test. HPV infection condition in different age groups and HPV infection condition in patients with different grades of cervical lesion were analyzed. Results A total of 352 patients were found with HPV infection, and the detection rate of HPV was 24.3%. The increase in age was positively correlated with HPV infection rate. The infection rate of HPV would increase with ages, and there was a significant difference in HPV infection rate among different age groups (P<0.05). The HPV infection rate would increase with increase in degree of cervical lesion, which indicated importance of regular cervical cancer screening for sexually active women. There were significant differences in HPV infection rate between cervical lesions of different grades (P<0.05). Conclusions The combined application of HPV typing test and cervical vaccine is conducive to the fluent progress of screening cervical cancer, and it can provide important reference basis for the prevention and treatment of cervical cancer.