异丙托溴铵联合孟鲁司特钠治疗小儿哮喘的效果及对肺功能的影响

Effects of ipratropium bromide combined with montelukast sodium on asthma and lung function in children

目的探讨异丙托溴铵联合孟鲁司特钠治疗小儿哮喘的效果及对肺功能的影响。方法选取滨州市中心医院2017年4月至2018年10月收治的哮喘患儿100例,随机分为两组。对照组应用孟鲁司特钠治疗,研究组联合应用异丙托溴铵治疗。观察比较两组哮喘患儿的临床疗效及治疗前后两组肺功能指标水平。结果研究组疗效优于对照组(P<0.05);治疗后,两组哮喘患儿第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、最大呼气流量(PEF)及FEV1/FVC均升高(P<0.05),且研究组FEV1、FVC、PEF及FEV1/FVC高于对照组(P<0.05);两组哮喘患儿IgE、白细胞介素-5(IL-5)降低、白细胞介素-10(IL-10)升高(P<0.05),且研究组IgE、IL-5低于对照组,IL-10高于对照组(P<0.05)。结论异丙托溴铵联合孟鲁司特钠治疗儿童哮喘的疗效显著,能有效缓解哮喘患儿的各项临床症状,改善患儿的肺功能指标及炎性因子水平,值得临床应用及推广。

Objective To investigate the efficacy of ipratropium bromide combined with montelukast sodium on pediatric asthma and its influence on pulmonary function. Methods A total of 100 cases of children with asthma hospitalized in Binzhou Central Hospital from April 2017 to October 2018 were selected and randomly divided into two groups. Children in control group were treated with montelukast sodium, and children in study group were treated with ipratropium bromide and montelukast sodium. The clinical efficacy of the two groups and the changes of pulmonary function indexes before and after treatment were observed and compared. Results The curative effect of study group was better than that of control group (P<0.05). After treatment, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF) and FEV1/FVC were significantly increased in the both groups (P<0.05). After treatment, FEV1, FVC, PEF and FEV1/FVC in study group were higher than those in control group (P<0.05). Levels of IgE and interleukin-5(IL-5) were significantly decreased and interleukin -10(IL-10) level was significantly increased in the two groups (P<0.05). Levels of IgE and IL-5 in study group were lower than those in control group, and IL-10 level was higher in study group than control group (P<0.05). Conclusions The combined application of ipratropium bromide and montelukast sodium has a significant effect on pediatric asthma. The protolol can effectively relieve the clinical symptoms, improve the pulmonary function index and inflammatory factor level of the children with asthma, so it is worthy of application and promotion.