银杏叶联合多奈哌齐治疗阿尔茨海默症的效果观察

Clinical observation on effects of ginkgo biloba combined with donepezil on Alzheimer’s disease

目的综合分析银杏叶联合多奈哌齐治疗阿尔茨海默症的临床效果。方法选取山西医科大学第二医院2013年10月至2016年10月收治的100例阿尔茨海默症患者为研究对象,按照治疗方法进行分组,采用银杏叶联合多奈哌齐治疗的50例患者纳入观察组,采用多奈哌齐治疗的50例患者纳入对照组。两组患者均连续治疗4个月,1个月为一疗程。采用SPSS 20.0统计学软件分析两组患者治疗前后简易精神状态评价量表评分、日常生活能力量表评分、长谷川痴呆量表评分、血液流变学指标(全血低切黏度、血浆黏度、全血高切黏度)等变化情况。结果治疗前,对照组与观察组简易精神状态评价量表评分、日常生活能力量表评分、长谷川痴呆量表评分比较差异未见统计学意义(P>0.05);治疗后,观察组简易精神状态评价量表评分、日常生活能力量表评分、长谷川痴呆量表评分与对照组比较差异有统计学意义(P<0.05)。治疗前,两组全血低切黏度、血浆黏度、全血高切黏度等血液流变学指标比较差异未见统计学意义(P>0.05);治疗后,观察组全血低切黏度、血浆黏度、全血高切黏度等血液流变学指标优于对照组(P<0.05)。结论银杏叶联合多奈哌齐治疗阿尔茨海默症的临床效果显著,且能够有效改善简易精神状态评价量表评分、日常生活能力量表评分、长谷川痴呆量表评分以及血液流变学指标。

Objective To comprehensively analyze the clinical effects of ginkgo biloba combined with donepezil on Alzheimer’s disease. Methods A total of 100 patients with Alzheimer’s disease hospitalized in Second Hospital of Shanxi Medical University from October 2013 to October 2016 were selected as research objects. And they were grouped according to treatment protocols;50 patients treated with ginkgo biloba combined with donepezil were allocated into observation group;and 50 patients treated with donepezil were allocated into control group. All patients were treated for 4 months, one month as a course of treatment. The scores of the simple mental status scale, the daily living ability scale score, the Hasegawa dementia scale and the hemorheology index (low shear blood viscosity, plasma viscosity, high shear blood viscosity) were analyzed between the two groups by SPSS 20.0 statistical software. Results Before treatment, the scores of simple mental state scale, daily life ability scale and Hasegawa dementia scale were not significantly different between the two goups (P>0.05). After treatment, the above indexes of observation group significantly different from control group (P<0.05). Before treatment, there was no significant difference in the low shear blood viscosity, plasma viscosity or high shear blood viscosity between the two groups (P>0.05). After treatment, the low shear blood viscosity, plasma viscosity, high shear blood viscosity of observation group were significantly better than those of control group (P<0.05). Conclusions The clinical effect of ginkgo biloba combined with donepezil in the treatment of senile dementia is significant, and the protocol can effectively improve the scores of simple mental state evaluation, daily life ability scale, Hanguokawa dementia scale and hemorheology index.