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双联抗血小板治疗非心源性缺血性脑卒中的疗效观察 被引量:5

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摘要 目的:研究采用双联抗血小板治疗非心源性缺血性脑卒中的临床疗效。方法:选取我院2016年3月~2018年3月收治的88例非心源性CIS患者为研究对象,分为两组。研究组44例接受硫酸氢氯吡格雷联合阿司匹林治疗,对照组44例接受阿司匹林治疗。比较两组临床疗效、复发率及不良反应。结果:研究组总有效率97.73%,高于对照组的70.45%;治疗后,研究组全血低切黏度(15.72±1.76) mPa·s、血小板聚集率(52.76±4.20)%、血浆黏度(1.55±0.30) mPa·s、NIHSS评分(6.71±1.06)分、复发率2.27%均比对照组(20.65±2.14) mPa·s、(63.39±5.13)%、(2.14±0.41) mPa·s、(17.20±1.53)分、18.18%低(均P<0.05)。治疗后两组纤维蛋白原水平与总不良反应发生率对比,差异无统计学意义(P>0.05)。结论:硫酸氢氯吡格雷联合阿司匹林治疗非心源性CIS患者,可改善患者神经缺损,降低疾病复发率,疗效较好。
作者 白艳华
出处 《实用中西医结合临床》 2019年第4期56-58,共3页 Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine
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  • 1曹瑞萍.非心源性缺血性脑卒中和创伤性脑损伤患者血清脂蛋白a水平的比较[J].临床研究,2014,22(8):20-21. 被引量:1
  • 2Chen ZM, Sandercock P, Pan HC, et al. Indications for early aspirin use in acute ischemic stroke a combined analysis of 40 000 randomized patients from the chinese acute stroke trial and the international stroke trial[J ]. Stroke, 2000, 31 (6): 12,40-1249.
  • 3Diener HC, Bogousslavsky J, Brass LM, et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo- controlled trial [J]. Lancet, 2004, 364(9431 ): 331-337.
  • 4Bhatt DL, Fox KA, Hacke W, et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events [J]. N EnglJ Med 2006, 354(16): 1706-1707.
  • 5SPS3 Investigators, Benavente OR, Hart RG, et al. Effects of clopidogrel added to aspirin in patients with recent lacunar stroke[J]. Y EnglJ Med, 2012, 367(9): 817-825.
  • 6Hankey GJ, Johnston SC, Easton JD, et al. Effect of clopidogrel plus ASA rs. ASA early after TIA and ischaemic stroke: a substudy of the CHARISMA trial[J]. Int J Stroke, 2011, 6(1): 3-9.
  • 7Kennedy J, Hill MD, Ryckborst KJ, et al. Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial[J]. Lancet Neurol, 2007, 6(11): 961-969.
  • 8Cohen SN. Letter regarding article by Markus et al, "Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic cardiac stenosis evaluated using doppler embolic signal detection: the clopidogrel and aspirin for reduction of emboli in symptomatic carotid stenosis (CARESS) trial"[J]. Circulation, 2005, 112(20): e325.
  • 9Wong KS, Chen C, Fu J, et al. Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial[J]. Lancet Neurol, 2010, 9(5) : 489-497.
  • 10Wang Y, Johnston SC, CHANCE Investigators. Rationale and design of a randomized, double-blind trial comparing the effects of a 3-month clopidogrel-aspirin regimen versus aspirin alone for the treatment of high-risk patientswith acute nondisabling cerebrovascular event[J]. Am Heart J, 2010, 160(3): 380-386.

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