扶康汤用于结直肠癌术后辅助化疗患者的临床观察

Clinical Observation on Fukang Tang Applied in the Colorectal Cancer Patients Undergoing Postoperative Adjuvant Chemotherapy

为探讨中药扶康汤口服对结直肠癌术后辅助化疗患者生存质量及化疗毒副反应的影响,将64例结直肠癌术后辅助化疗患者随机分为治疗组和对照组,各32例。治疗组术后采用mFOLFOX6方案化疗并联合扶康汤口服,对照组术后单纯采用mFOLFOX6方案化疗。观察2组治疗12周前后的临床效果,评估患者生存质量改变及化疗不良反应的差别。结果显示,治疗结束后2组患者卡氏评分较治疗前均有所提高,且治疗组优于对照组,差异有统计学意义(P <0.05)。治疗组化疗后白细胞减少、血小板减少、血红蛋白减少、恶心呕吐、腹痛腹泻等不良反应较对照组明显减轻,差异具有统计学意义(P <0.05)。结果表明,扶康汤口服能减轻结直肠癌患者术后辅助化疗的不良反应,提高患者生存质量。

To investigate the influence of Fukang Tang(a TCM formula,shortly named as Tang)on the life quality and untoward reaction of chemotherapy in the colorectal cancer patient undergoing postoperative adjuvant chemotherapy,this study randomly divided 64cases into treatment group and control one(32cases, for each);the former received postoperative mFOLFOX6chemotherapy scheme plus oral Tang,while the latter alone postoperative mFOLFOX6chemotherapy scheme;then observed clinical efficacy before and after treatment of 12weeks,evaluated patients'quality of life and untoward reaction.As results,after the end of treatment both groups'KPS all uplifted than before,but the former was superior to the latter,there was statistical difference between the two groups(P <0.05);in the former after chemotherapy untoward reactions(leukopenia,thrombocytopenia,hemoglobin reduction,nausea &vomiting,abdominal pain,diarrhea, etc.)got more improved than those in the latter,there was statistical difference between the two groups(P <0.05).Results show that orally administering Tang can reduce unward reaction from postoperative adjuvant chemotherapy,enhance patients'quality of life.