男性2型糖尿病合并甲状腺结节患者的临床特征

Clinical characteristics of male patients with type 2 diabetes mellitus complicated with thyroid nodule

目的分析2型糖尿病(T2DM)合并甲状腺结节(TN)男性患者的临床特征。方法男性T2DM患者111例中,41例合并TN(TN组),70例不合并TN(non-TN组),比较两组年龄、BMI、糖脂代谢指标、性激素水平和甲状腺功能等指标差异。结果 TN组年龄[(56.70±10.79)岁vs.(50.15±11.74)岁]、BMI[(25.70±3.16) kg/m^2 vs.(24.39±2.49) kg/m^2]、HbA1c[(9.93±2.49)%vs.(8.97±2.13)%]、HOMA-IR(3.48±1.47 vs. 2.62±2.17)、TG[(2.58±2.25) mmol/L vs.(1.76±1.29) mmol/L]和FT_4水平[(36.79±31.22) pmol/L vs.(28.89±15.92) pmol/L]均高于non-TN组(P<0.05或P<0.01);脱氢表雄酮(DHEA)低于non-TN组[(4.54±2.28)μmol/L vs.(5.97±2.93)μmol/L](P<0.05)。结论胰岛素抵抗在男性T2DM合并TN患者中更为严重,糖脂代谢更加紊乱,DHEA水平更低。

Objective To analyze clinical characteristics of male patients with type 2 diabetes mellitus(T2 DM) complicated with thyroid nodule(TN).Methods A total of 111 male patients with T2 DM was divided into two groups of TN(41 cases) and non-TN(70 cases).The differences of age,BMI,glucolipid metabolisms and the level of sex hormones and thyroid function were compared between two groups.Results Compared with group non-TN,the age [(56.70±10.79) years old vs.(50.15±11.74) years old],BMI [(25.70±3.16) kg/m^2 vs.(24.39±2.49) kg/m^2],HbA1 c [(9.93±2.49)% vs.(8.97±2.13)%],insulin resistance index(3.48±1.47 vs.2.62±2.17),TG [(2.58±2.25) mmol/L vs.(1.76±1.29) mmol/L] and FT4 level [(36.79±31.22) pmol/L vs.(28.89±15.92) pmol/L] were all higher in group NT(P<0.05 or P<0.01),but dehydroepiandrosterone(DHEA) was lower in group NT [(4.54±2.28)μmol/L vs.(5.97±2.93)μmol/L](P<0.05).Conclusion Male T2 DM patients complicated with TN are more prone to have disturbances in insulin resistance and glucolipid metabolisms as well as lower level of DHEA.