血清尿酸与认知功能障碍/痴呆的研究进展

Advances in research on the relationship between serum uric acid level and cognitive impairment/dementia

尿酸是通过人体外源性摄入及体内嘌呤化合物在肝脏代谢中产生的,现已知尿酸对高血压、糖尿病、慢性肾脏疾病及痛风有影响,并有研究表明其为心血管疾病的危险因素,但目前对于认知功能的影响尚存在争议。随着社会人口老龄化的日益加剧,患认知功能障碍人数增加,这成为社会及家庭极大负担,目前对于认知功能障碍并没有较好的治疗方法,积极控制危险因素,预防认知功能障碍的发生极为重要。

Uric acid(UA) is produced by human exogenous intake and purine compounds in liver metabolism,which is known to have an impact on hypertension,diabetes,chronic kidney disease and gout.Studies have shown that it is a risk factor for cardiovascular disease.However,its impact on cognitive function is still controversial.With the aging of the social population,the number of people with cognitive dysfunction increases,which is a great burden for society and the family.At present,there is no good treatment for cognitive dysfunction,and it is extremely important to actively control risk factors and prevent the occurrence of cognitive dysfunction.