替加环素致低纤维蛋白原血症1例及文献复习

Hypofibrinogenemia induced by tigecycline:a case report and review of literature

本文报道1例重症加强护理病房患者使用高剂量替加环素引起低纤维蛋白原血症的病例,并通过文献检索和综述,对这些患者的一般情况、原患疾病、药物治疗过程等因素进行分析。结合文献报道,发现替加环素和低纤维蛋白原血症的发生存在相关性,可能发生在使用替加环素5～7d,并且纤维蛋白原的下降是持续性的,一旦停止使用替加环素,纤维蛋白原在5d内恢复至正常水平。在使用替加环素过程中,应严密监测患者的凝血功能和纤维蛋白原水平。

There are few literature reports about tigecycline associated hypofibrinogenemia, We report a case of life-threatening hypofibrinogenemia in a 63-year-old male patient with severe infections treated with high-dose tigecycline. Through, we believed that tigecycline was associated with hypofibrinogenemia based on literatures. Tigecycline-associated coagulopathy might occur within 7 days after using tigecycline, and the patient got impoved within 5 days after tigecycline discontinuation. We suggest that coagulation parameters and fibrinogen should be closely monitored during tigecycline received.