首发未服药焦虑障碍患者脑白质弥散张量成像的对照研究

A comparative study of the white matter by using diffusion tensor imaging in first-episode,medicationna?ve anxiety disorders

目的应用磁共振弥散张量成像(DTI)比较首发未服药的焦虑障碍患者和正常被试者的脑白质纤维完整性差异。方法选择符合条件的20例首发未服药焦虑障碍患者为研究组,25名条件匹配的正常健康人为对照组,所有受试者采用1.5 Tesla MRI扫描收集弥散张量成像(DTI)测量兴趣区(ROI)纤维束的部分各向异性(FA)值和表观弥散系数(ADC),并行比较。结果研究组在右侧放射冠的FA值(0.44±0.02)低于正常对照组(0.47±0.02),左侧内囊前肢FA值(0.49±0.08)高于正常对照组(0.46±0.04),右侧前扣带回的ADC值(8.64±0.45)高于正常对照组(8.03±0.34),差异均有统计学意义(P<0.05)。结论焦虑障碍患者存在内囊前后肢、胼胝体膝部和压部、放射冠、前扣带回、背侧丘脑等脑白质丰富区域的白质完整性受损,这些异常可能是焦虑障碍发病的重要病理生理机制。

Objective To explore the difference of white matter integrity between first-episode,medicationna-ve patients with anxiety disorder and normal subjects by using diffusion tensor imaging(DTI). Methods 20 firstepisode,medication-na-ve anxiety disorders and 25 healthy controls were scanned by using a General Electric 1.5 Tesla MRI and diffusion tensor Imaging. Functlool 7.4.01 d software was used to calculate the fractional anisotropy(FA)and apparent diffusion coefficient(ADC)value of region of interesting(ROI)in two groups. Results The FA value of right corona radiate in anxiety disorders was lower than normal controls,the FA value of left anterior limb in anxiety disorders was higher than the normal controls,The ADC value of right anterior cingulate in anxiety disorders was higher than the normal controls,the difference between the two groups was statistically significant(P<0.05). Conclusion Patients with anxiety disorder have white matter integrity abnormalities,which includes the anterior and the posterior limb of internal capsule,the genu and the splenium of the corpus callosum,the right corona radiata,the right anterior cingulum,and the thalamus. Suggest that these abnormalities may play a key role in the pathophysiology of anxiety disorder.