单相抑郁患者缓解期认知功能损害观察

Cognitive impairment in patients with unipolar depression during remission

目的探讨单相抑郁患者缓解期的认知功能状况。方法对58例单相抑郁患者在发作期和缓解期(试验组)及30名健康对照者(对照组)进行WCST、CPT、TMT和CWT,并对结果进行比较和分析。结果 WCST:试验组发作期的正确反应数及完成分类数少于缓解期,错误总数、持续错误数及随机错误数多于缓解期(P<0.05);试验组发作期及缓解期的正确反应数及完成分类数少于对照组,总测验次数、错误总数、持续错误数及随机错误数多于对照组(P<0.05)。CPT:试验组发作期的正确反应数1、2、3少于缓解期,错误次数1、2、3多于缓解期(P<0.05);试验组发作期及缓解期的正确反应数1、2、3少于对照组,错误次数1、2、3及持续错误数多于对照组(P<0.05)。TMT:试验组发作期的连线测验A、B用时长于缓解期(P<0.05);试验组发作期及缓解期的连线测验A、B用时长于对照组(P<0.05)。CWT:试验组发作期的色词测验A、B、C用时长于缓解期(P<0.05);试验组发作期及缓解期的色词测验A、B、C用时长于对照组(P<0.05)。结论缓解期患者的认知功能虽较发作期有所改善,但仍达不到健康人的水平。

Objective Objective to explore the cognitive function of patients with unipolar depression during remission. Method WCST、CPT、TMT and CWT were performed in 58 patients with unipolar depression during stage of attack and remission(experimental group)and 30 healthy controls(control group). Result WCST :In the trial group the number of correct responses and complete classifications in patients with episodes was less than that in remission,and the total number of errors,the number of persistent errors and the number of random errors were more than that in remission(P<0.05);The number of correct reactions and complete classifications in the trial group were less than those in the control group,and the number of total tests,total errors,persistent errors and random errors in the trial group were more than those in the control group(P<0.05). CPT :In the trial group the number of correct responses 1,2 and 3 in patients with episodes was less than that in remission,and the number of errors 1,2 and 3 was more than that in remission(P<0.05);The number of correct responses 1,2 and 3 in the trial group was less than that in the control group,and the number of errors 1,2,3 and persistent errors in the trial group were more than that in the control group(P<0.05). TMT :In the trial group the A and B of the patients in the attack phase were longer than those in the remission stage(P<0.05);In the trial group,the A and B of the test group were longer than those of the control group at both the onset stage and the remission stage(P<0.05). CWT :In the trial the color words test A,B and C were longer in the attack phase than in remission stage(P<0.05);The color words test A,B and C in the trial group were longer than those in the control group at both the onset stage and the remission stage(P<0.05). Conclusion The cognitive function of patients in remission stage is better than that in attack stage,but it still can not reach the level of healthy control.