OSAHS患者血中NLR水平与认知功能的关系

Relationship between blood NLR level and cognitive function in OSAHS patients

目的探讨阻塞型睡眠呼吸暂停低通气综合征(OSAHS)患者血中性粒细胞/淋巴细胞比值(NLR)水平与认知功能的关系。方法将66例OSAHS患者分为轻度组(n=16)、中度组(n=15)和重度组(n=35),选择25例健康者作对照组。用多导睡眠监测仪(PSG)监测患者夜间睡眠呼吸暂停低通气指数(AHI)和最低血氧饱和度(LSaO2),采用MMSE和MoCA量表评判患者认知功能,检测4组NLR水平。分析认知功能量表评分、AHI、LSaO2与NLR之间相关性。结果与对照组比较,中、重度组MMSE、MoCA评分降低;与轻度组比较,重度组MMSE、MoCA评分降低(P<0.05);OSAHS患者MMSE、MoCA评分与AHI呈负相关(r=-0.472和-0.768,P<0.05),与LSaO2呈正相关(r=0.672和0.741,P<0.05)。与对照组、轻度组比较,重度组NLR水平升高(P<0.05)。OSAHS患者NLR水平与AHI呈正相关(r=0.2594,P<0.05),与LSaO2呈负相关(r=-0.2423,P<0.05);OSAHS患者MMSE、MoCA评分与NLR呈负相关(r=-0.3225和-0.3299,P<0.05)。结论 OSAHS患者NLR水平随着AHI增加和缺氧程度加重而升高,NLR升高与认知功能下降具有相关性,早期对OSAHS患者NLR进行筛查,对病情评估具有一定参考价值。

Objective To investigate the relationship between blood neutrophil/lymphocyte ratio(NLR)and cognitive function in patients with obstructive sleep apnea hypopnea syndrome(OSAHS). Methods 66 OSAHS patients were divided into mild group(n=16),moderate group(n=15)and severe group(n=35),and 25 healthy subjects were selected as the control group. Polysomnography monitor(PSG)was used to monitor the AHI and LSaO2 of the patients. MMSE and MoCA scales were used to evaluate the cognitive function of the patients. The levels of NLR in the blood of the 4 groups were measured. To analyze the correlation among cognitive function scale scores,AHI,LSaO2 and NLR. Results Compared with the control group,MMSE and MoCA scores of moderate and severe groups were decreased. OSAHS patients’ MMSE and MoCA scores was negatively correlated with AHI and positively correlated with LSaO2. Compared with the control group,the levels of leukocyte,neutrophil and NLR in moderate and severe group were increased(P<0.05). OSAHS patients’ blood NLR level was positively correlated with AHI d negatively correlated with LSaO2. OSAHS patients’ MMSE and MoCA score is negatively correlated with NLR. Conclusion The blood NLR level of OSAHS patients increases with the increase of AHI and the aggravation of hypoxia,and there is a certain correlation between the increase of blood NLR level and cognitive function dysfunction. Early screening of OSAHS patients’ NLR has certain reference value for disease evaluation.