摘要
Dear Editor,Lipid droplets(LDs)are dynamic lipid-storage organelles of storage depots and sources of essential substrates for myriad cellular processes and protect cells from lipotoxicity(Ohsaki et al.,2006).Disrupted LD and fat storage homeostasis has been linked to metabolic diseases such as atherosclerosis,obesity,and type II diabetes(Levin et al.,2001).Structurally,the core of neutral lipids in LDs is surroun ded by a phospholipid mono layer and coated with specific proteins(Storey et al.,2011).Perilipin family of proteins are the predominant LD-associated proteins.
基金
the National Key Research and Development Program of China(2017YFA0102801,2018YFA0107 003)
National Natural Science Foundation of China(Grant Nos.91640119,91749113,81330055,31570827 and 31871479)
Guangzhou Science and Technology Project(201605030012)
Natural Science Foundation of Guangdong Province(2017A03031 3116)
Guangdong Science and Technology Department Planning Project(2015B020228002)
the NIH(HL131744 and CA211653)
the Welch Foundation(Q-1673 and I-1441)
CPRITRP160462
the C-BASS Shared Resource at the Dan L.Duncan Cancer Center(DLDCC)of Baylor College of Medicine(P30CA125123).
